Video

What Kids Wear Could Determine How Much Exercise They Get

Few College Students Have Received the H1N1 Vaccine

Night Lights Could Lead to Depression

Cervarix Has Been Approved by the FDA

The FDA Is Studying the Effects of Lasik Surgery

Painkillers Can Dull the Effects of Childhood Vaccines

Childbirth May Becoming More Complicated

Botox Sponges Might Help Nose Allergies

The FDA Advises on How to Properly Dispose of Medicine

A French Study Shows Cell Phones Do Not Affect Humans

MRIs May Lead to More Back Surgery

Your More Likely to Wash Your Hands If Someone's Watching

Co-Sleeping Is a Leading Cause of SIDS

Night Shifts Don't Have a Major Effect On Surgeons

Exercise May Counter Fatigue from Chemotherapy

Synthetic Protein Thwarts HIV Infection in Lab

Posted on 08/17/2009, 14:00
By -- Jennifer Thomas

By blocking cellular interaction, researchers prevent disease production

MONDAY, Aug. 17 (HealthDay News) -- Researchers report they were able to block HIV infections in the lab with synthetic proteins that prevented the virus from entering healthy cells.

In the study, researchers developed synthetic molecules that interfered with the ability of a key HIV protein called gp41 to interact with proteins in host cells.

By interrupting the interaction, HIV could not infect the cells, according to the study that appears online Aug. 17 in the Proceedings of the National Academy of Sciences.

Interactions among proteins occur as part of biological processes, including infections and tumor growth, the researchers explained.

"There's a lot of information transfer that occurs when proteins come together, and one would often like to block that information flow," Samuel Gellman, a chemistry professor at the University of Wisconsin-Madison, said in a news release from the school.

Past attempts to prevent infection by selectively interfering with protein interactions have had limited success, he said. Most drugs are not effective at blocking protein-to-protein interactions.

Short snippets of proteins, or peptides, have been shown to be somewhat effective, but they are easily broken down by enzymes in the body, according to the news release.

The new synthetic peptide-like molecules overcome that because of a modified structure that enzymes have trouble recognizing.

In the study, the synthetic molecules interacted with gp41 to prevent the virus from infecting host cells. The synthetic molecules were altered to improve their ability to withstand enzyme degradation, yet retained the three-dimensional shape necessary to recognize HIV's gp41 protein.

"We want to find an alternate language, an alternate way to express the information that the proteins express so that we can interfere with a conversation that one protein is having with another," Gellman explained.

The idea shows promise in developing treatments for other disease-causing protein interactions as well, including influenza and Ebola virus, Gellman added.

The study was supported by grants from the U.S. National Institutes of Health.

More information

The U.S. Centers for Disease Control and Prevention has more on HIV.

SOURCE: University of Wisconsin-Madison, news release, Aug. 17, 2009

More news in HIV & AIDS...

BigHealthTree.com Disclaimer

Bighealthtree.com Does Not Provide Medical Advice. This site, including the above information, is for informational purposes only and is not a substitute for professional medical or health advice. Always seek the advice of your physician or a qualified health or medical professional before starting any new treatment, changing existing treatment, or altering your current exercise and/or diet program. If you think you are having a medical emergency, call 911 (or the emergency services in your area) or your doctor immediately.

Rating: 2.9 / 5 (360 votes)